Protein phosphatases are involved in the in vivo activation of histone H1 kinase in mouse oocyte.

@article{Rime1990ProteinPA,
  title={Protein phosphatases are involved in the in vivo activation of histone H1 kinase in mouse oocyte.},
  author={H{\'e}l{\`e}ne Rime and Ren{\'e} Ozon},
  journal={Developmental biology},
  year={1990},
  volume={141 1},
  pages={115-22}
}
Histone H1 kinase and protein phosphorylation have been studied in mouse oocyte. Histone H1 kinase activity increases when the oocyte enters M-phase at the time of GVBD and is paralleled with a burst of protein phosphorylation. This activity dramatically drops after parthenogenetic activation induced by puromycin. Okadic acid (OA), a potent inhibitor of protein phosphatases, induces GVBD when oocytes are arrested in the first meiotic prophase by dbc-AMP; the continuous presence of the… CONTINUE READING

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