Protein phosphatases and calcium/calmodulin-dependent protein kinase II-dependent synaptic plasticity.

@article{Colbran2004ProteinPA,
  title={Protein phosphatases and calcium/calmodulin-dependent protein kinase II-dependent synaptic plasticity.},
  author={Roger J Colbran},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2004},
  volume={24 39},
  pages={8404-9}
}
  • Roger J Colbran
  • Published 2004 in
    The Journal of neuroscience : the official…
Synaptic plasticity in hippocampal CA1 pyramidal cells requires a delicate balance of protein kinase and protein phosphatase activities. Long-term potentiation (LTP) after intense synaptic stimulation often results from postsynaptic Ca 2 influx via NMDAtype glutamate receptors and activation of multiple protein kinases. In contrast, weaker synaptic stimulation paradigms can induce long-term depression (LTD) (or depotentiation of previous LTP) via NMDA receptor-dependent activation of protein… CONTINUE READING

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