Protein phosphatases 1 and 2A regulate the transcriptional and DNA binding activities of retinoic acid receptors.

@article{Lefebvre1995ProteinP1,
  title={Protein phosphatases 1 and 2A regulate the transcriptional and DNA binding activities of retinoic acid receptors.},
  author={Philippe Lefebvre and Marie Pierre Gaub and A Tahayato and C{\'e}cile Rochette-Egly and Pierre Formstecher},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 18},
  pages={10806-16}
}
To determine which factors may regulate the DNA binding and transcriptional properties of retinoic acid receptors (RARs and RXRs), we investigated the sensitivity of reporter genes bearing various retinoic acid response elements (RAREs) to protein phosphatases (PPases) inhibition. PPases inhibition by okadaic acid led to an increase of the reporter genes activity in a RARE-dependent and ligand-independent manner and was dependent on the type of response element used. Overexpression of protein… CONTINUE READING
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