Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor–induced apoptosis

@article{Xing2005ProteinPS,
  title={Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor–induced apoptosis},
  author={Yan Xing and Hideya Igarashi and Xiaodan Wang and Nobuo Dr Sakaguchi},
  journal={The Journal of Experimental Medicine},
  year={2005},
  volume={202},
  pages={707 - 719}
}
B cell receptor (BCR) cross-linking induces B cell proliferation and sustains survival through the phosphorylation-dependent signals. We report that a loss of the protein phosphatase component G5PR increased the activation-induced cell death (AICD) and thus impaired B cell survival. G5PR associates with GANP, whose expression is up-regulated in mature B cells of the peripheral lymphoid organs. To study G5PR function, the G5pr gene was conditionally targeted with the CD19-Cre combination (G5pr… CONTINUE READING

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