Protein phosphatase PP1 is required for normal DNA methylation in Neurospora.

@article{Adhvaryu2008ProteinPP,
  title={Protein phosphatase PP1 is required for normal DNA methylation in Neurospora.},
  author={Keyur K. Adhvaryu and Eric U Selker},
  journal={Genes & development},
  year={2008},
  volume={22 24},
  pages={3391-6}
}
Covalent modifications of histones integrate intracellular and extracellular cues to regulate the genome. H3 Lys 9 methylation (H3K9me) can direct heterochromatin formation and DNA methylation, while phosphorylation of H3 Ser 10 (H3S10p) drives gene activation and chromosome condensation. To examine the relationship between H3S10p, H3K9me, and DNA methylation in Neurospora crassa, we built and tested mutants of the putative H3S10 phosphatase, PP1. A PP1-impaired mutant showed increased H3S10p… CONTINUE READING

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