Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon.

@article{Stefansson2006ProteinP6,
  title={Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon.},
  author={Bjarki Stefansson and David L. Brautigan},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 32},
  pages={22624-34}
}
Protein Ser/Thr phosphatases compose a PPP family that includes type-2 PP2A, PP4, and PP6, each with essential functions. The human PP6 gene rescues sit4(ts) mutants of Saccharomyces cerevisiae, and Sit4 phosphatase function depends on multiple Sit4-associated protein (SAP) subunits. We report here finding a SAPS sequence domain encoded in only a single gene each in Schizosaccharomyces pombe, Caenorhabditis elegans, and Drosophila but in three distinct open reading frames in Xenopus, Mus… CONTINUE READING