Protein phosphatase 2C is responsible for VP-induced dephosphorylation of AQP2 serine 261.

@article{Cheung2017ProteinP2,
  title={Protein phosphatase 2C is responsible for VP-induced dephosphorylation of AQP2 serine 261.},
  author={Pui W Cheung and Lars Ueberdiek and Jack Day and Richard Bouley and Dennis L. Brown},
  journal={American journal of physiology. Renal physiology},
  year={2017},
  volume={313 2},
  pages={
          F404-F413
        }
}
Aquaporin 2 (AQP2) trafficking is regulated by phosphorylation and dephosphorylation of serine residues in the AQP2 COOH terminus. Vasopressin (VP) binding to its receptor (V2R) leads to a cascade of events that result in phosphorylation of serine 256 (S256), S264, and S269, but dephosphorylation of S261. To identify which phosphatase is responsible for VP-induced S261 dephosphorylation, we pretreated cells with different phosphatase inhibitors before VP stimulation. Sanguinarine, a specific… CONTINUE READING
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