Protein phosphatase 2A is targeted to cell division control protein 6 by a calcium-binding regulatory subunit.

@article{Davis2008ProteinP2,
  title={Protein phosphatase 2A is targeted to cell division control protein 6 by a calcium-binding regulatory subunit.},
  author={Anthony J. Davis and Zhen Yan and Bobbie Martinez and Marc C. Mumby},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 23},
  pages={16104-14}
}
The cell division control protein 6 (Cdc6) is essential for formation of pre-replication complexes at origins of DNA replication. Phosphorylation of Cdc6 by cyclin-dependent kinases inhibits ubiquitination of Cdc6 by APC/C(cdh1) and degradation by the proteasome. Experiments described here show that the PR70 member of the PPP2R3 family of regulatory subunits targets protein phosphatase 2A (PP2A) to Cdc6. Interaction with Cdc6 is mediated by residues within the C terminus of PR70, whereas… CONTINUE READING
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Targets PP2A to Cdc6 16114 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

  • X. Li, D. M. Virshup
  • Eur. J. Biochem
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