Protein phosphatase 2A interacts with the Src kinase substrate p130(CAS).

@article{Yokoyama2001ProteinP2,
  title={Protein phosphatase 2A interacts with the Src kinase substrate p130(CAS).},
  author={Noriko Yokoyama and W Todd Miller},
  journal={Oncogene},
  year={2001},
  volume={20 42},
  pages={6057-65}
}
In this study, we report that the Src substrate Cas (p130 Crk-associated substrate) associates with protein phosphatase 2A (PP2A), a serine/threonine phosphatase. We investigated this interaction in cells expressing a temperature-sensitive mutant form of v-Src. v-Src activation (by shifting cells from the nonpermissive to the permissive temperature) led to an increase in the tyrosine phosphorylation of v-Src and Cas, as well as in the association between v-Src and Cas. v-Src has previously been… CONTINUE READING