Protein phosphatase 2A dysfunction in Alzheimer’s disease

  title={Protein phosphatase 2A dysfunction in Alzheimer’s disease},
  author={J. -M. Sontag and Estelle Sontag},
  booktitle={Front. Mol. Neurosci.},
Protein phosphatase 2A (PP2A) is a large family of enzymes that account for the majority of brain Ser/Thr phosphatase activity. While PP2A enzymes collectively modulate most cellular processes, sophisticated regulatory mechanisms are ultimately responsible for ensuring isoform-specific substrate specificity. Of particular interest to the Alzheimer's disease (AD) field, alterations in PP2A regulators and PP2A catalytic activity, subunit expression, methylation and/or phosphorylation, have been… CONTINUE READING
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