Protein phosphatase 1 subunit Ppp1r15a/GADD34 regulates cytokine production in polyinosinic:polycytidylic acid-stimulated dendritic cells.

@article{Clavarino2012ProteinP1,
  title={Protein phosphatase 1 subunit Ppp1r15a/GADD34 regulates cytokine production in polyinosinic:polycytidylic acid-stimulated dendritic cells.},
  author={Giovanna Clavarino and Nuno Cl{\'a}udio and Alexandre Dalet and Seigo Terawaki and Th{\'e}r{\`e}se Couderc and Lionel Chasson and Maurizio Ceppi and Enrico K. Schmidt and Till Wenger and Marc Lecuit and Evelina Gatti and Philippe Pierre},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 8},
  pages={3006-11}
}
In response to inflammatory stimulation, dendritic cells (DCs) have a remarkable pattern of differentiation that exhibits specific mechanisms to control the immune response. Here we show that in response to polyriboinosinic:polyribocytidylic acid (pI:C), DCs mount a specific integrated stress response during which the transcription factor ATF4 and the growth arrest and DNA damage-inducible protein 34 (GADD34/Ppp1r15a), a phosphatase 1 (PP1) cofactor, are expressed. In agreement with increased… CONTINUE READING