Protein phosphatase-1 regulation in the induction of long-term potentiation: heterogeneous molecular mechanisms.

@article{Allen2000ProteinPR,
  title={Protein phosphatase-1 regulation in the induction of long-term potentiation: heterogeneous molecular mechanisms.},
  author={Philip B. Allen and Oivind Hvalby and Vidar Jensen and Michael L Errington and Mich{\'e}le Ramsay and Farrukh Abbas Chaudhry and Tim V.P. Bliss and Jon Storm-Mathisen and Richard G. M. Morris and Per Oskar Andersen and Paul Greengard},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2000},
  volume={20 10},
  pages={3537-43}
}
Protein phosphatase inhibitor-1 (I-1) has been proposed as a regulatory element in the signal transduction cascade that couples postsynaptic calcium influx to long-term changes in synaptic strength. We have evaluated this model using mice lacking I-1. Recordings made in slices prepared from mutant animals and also in anesthetized mutant animals indicated that long-term potentiation (LTP) is deficient at perforant path-dentate granule cell synapses. In vitro, this deficit was restricted to… CONTINUE READING

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