Protein phosphatase 1 modulates the inhibitory effect of With-no-Lysine kinase 4 on ROMK channels.

@article{Lin2012ProteinP1,
  title={Protein phosphatase 1 modulates the inhibitory effect of With-no-Lysine kinase 4 on ROMK channels.},
  author={Daohong Lin and Peng Yue and Jesse Rinehart and Peng Sun and Zhijian Wang and Richard P. Lifton and Wenhui Wang},
  journal={American journal of physiology. Renal physiology},
  year={2012},
  volume={303 1},
  pages={F110-9}
}
With-no-Lysine kinase 4 (WNK4) inhibited ROMK (Kir1.1) channels and the inhibitory effect of WNK4 was abolished by serum-glucocorticoid-induced kinase 1 (SGK1) but restored by c-Src. The aim of the present study is to explore the mechanism by which Src-family tyrosine kinase (SFK) modulates the effect of SGK1 on WNK4 and to test the role of SFK-WNK4-SGK1 interaction in regulating ROMK channels in the kidney. Immunoprecipitation demonstrated that protein phosphatase 1 (PP1) binds to WNK4 at… CONTINUE READING