Protein phosphatase 1 is targeted to microtubules by the microtubule-associated protein Tau.

@article{Liao1998ProteinP1,
  title={Protein phosphatase 1 is targeted to microtubules by the microtubule-associated protein Tau.},
  author={H Liao and Yi Li and David L. Brautigan and Gregg G. Gundersen},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 34},
  pages={21901-8}
}
Phosphorylation has been implicated in the regulation of microtubule (MT) stability and function by controlling the interactions between MTs and MT-associated proteins. We found previously that protein phosphatase inhibitors selectively break down stable MTs, suggesting that protein phosphatases may be involved in regulating MT stability. To identify the protein phosphatases involved, we examined purified calf brain MTs and found a protein phosphatase activity that copurified with MTs to… CONTINUE READING

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