Protein phosphatase 1 binds to the RNA recognition motif of several splicing factors and regulates alternative pre-mRNA processing.

@article{Novoyatleva2008ProteinP1,
  title={Protein phosphatase 1 binds to the RNA recognition motif of several splicing factors and regulates alternative pre-mRNA processing.},
  author={Tatyana Novoyatleva and Bettina M. Heinrich and Yesheng Tang and Natalya Benderska and Matthew E R Butchbach and Christian L. Lorson and Monique A. Lorson and Claudia Ben-Dov and Pascale Fehlbaum and Laurent Bracco and Arthur H. M. Burghes and Mathieu Bollen and Stefan Stamm},
  journal={Human molecular genetics},
  year={2008},
  volume={17 1},
  pages={
          52-70
        }
}
Alternative splicing emerges as one of the most important mechanisms to generate transcript diversity. It is regulated by the formation of protein complexes on pre-mRNA. We demonstrate that protein phosphatase 1 (PP1) binds to the splicing factor transformer2-beta1 (tra2-beta1) via a phylogenetically conserved RVDF sequence located on the RNA recognition motif (RRM) of tra2-beta1. PP1 binds directly to tra2-beta1 and dephosphorylates it, which regulates the interaction between tra2-beta1 and… CONTINUE READING

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