Protein phosphatase 1 binds to phospho-Ser-1394 of the macrophage-stimulating protein receptor.

@article{Santoro2003ProteinP1,
  title={Protein phosphatase 1 binds to phospho-Ser-1394 of the macrophage-stimulating protein receptor.},
  author={Massimo M Santoro and Giovanni Gaudino and Emma Villa-Moruzzi},
  journal={The Biochemical journal},
  year={2003},
  volume={376 Pt 3},
  pages={587-94}
}
The tyrosine kinase Ron, receptor for MSP (macrophage-stimulating protein), displays several serine residues of unknown functions. Using [(32)P]H(3)PO(4) metabolic labelling, we found that Ron is serine-phosphorylated and dephosphorylated in vitro by PP1 (protein phosphatase 1). PP1 associates with Ron obtained from cells of different origins. The association is stimulated by MSP or serum and is prevented by wortmannin, an inhibitor of the Akt/PKB (protein serine/threonine kinase B) pathway… CONTINUE READING

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