Protein phosphatase 1--targeted in many directions.

  title={Protein phosphatase 1--targeted in many directions.},
  author={Patricia T. W. Cohen},
  journal={Journal of cell science},
  volume={115 Pt 2},
Protein phosphatase 1 (PP1) is a major eukaryotic protein serine/threonine phosphatase that regulates an enormous variety of cellular functions through the interaction of its catalytic subunit (PP1c) with over fifty different established or putative regulatory subunits. Most of these target PP1c to specific subcellular locations and interact with a small hydrophobic groove on the surface of PP1c through a short conserved binding motif--the RVxF motif--which is often preceded by further basic… CONTINUE READING
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