Protein permeability in the adult respiratory distress syndrome. Loss of size selectivity of the alveolar epithelium.

@article{Holter1986ProteinPI,
  title={Protein permeability in the adult respiratory distress syndrome. Loss of size selectivity of the alveolar epithelium.},
  author={J F Holter and Johannes Weiland and Eric R. Pacht and James E. Gadek and William B. Davis},
  journal={The Journal of clinical investigation},
  year={1986},
  volume={78 6},
  pages={1513-22}
}
Small amounts of plasma protein normally reach the alveolar epithelial surface by a size-selective process that restricts the passage of very large molecules. Size selectivity may be compromised in the lungs of patients with the adult respiratory distress syndrome (ARDS). To assess this question, bronchoalveolar lavage fluid (BALF) from normal volunteers (n = 11), cardiac edema patients (n = 3), and ARDS patients (n = 8) was compared. Mean total protein in ARDS BALF was greater than 12 times… CONTINUE READING

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