Protein-passivated Fe(3)O(4) nanoparticles: low toxicity and rapid heating for thermal therapy.

Abstract

Thermotherapy is a promising technique for the minimally invasive elimination of solid tumors. Here we report the fabrication of protein-coated iron oxide NPs (12 nm core) for use as thermal therapeutic agents. These albumin-passivated NPs are stable under physiological conditions, with rapid heating and cell killing capacity upon alternating magnetic field (AMF) exposure. The mode of action is specific: no measurable cytotoxicity was observed for the particle without AMF or for AMF exposure without the particle.

6 Figures and Tables

Cite this paper

@article{Samanta2008ProteinpassivatedFN, title={Protein-passivated Fe(3)O(4) nanoparticles: low toxicity and rapid heating for thermal therapy.}, author={Bappaditya Samanta and Haoheng Yan and Nicholas O. Fischer and Jing Shi and D. Joseph Jerry and Vincent M Rotello}, journal={Journal of materials chemistry}, year={2008}, volume={18 11}, pages={1204-1208} }