• Corpus ID: 6235208

Protein palmitoylation and dynamic modulation of protein function

@article{Basu2004ProteinPA,
  title={Protein palmitoylation and dynamic modulation of protein function},
  author={Joyoti Basu},
  journal={Current Science},
  year={2004},
  volume={87},
  pages={212-217}
}
  • J. Basu
  • Published 2004
  • Biology
  • Current Science
The function of palmitoylation will depend on the protein that is being considered. Palmitoylation increases the hydrophobicity of proteins and contributes to their membrane association. Progress has been made in our understanding of protein S-palmitoylation as one of a repertoire of dynamic post-translational protein modifications that can control protein trafficking, localization, partitioning into domains, protein-protein interactions and functions. Some light has also been shed on the… 

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References

SHOWING 1-10 OF 76 REFERENCES
Immunity
TLDR
This theory, supported by an imposing array of facts, was ably presented by Mr. E. H. Hankin, who states that immunity, whether natural or acquired, is due to the presence of substances which are formed by the metabolism of the animals rather than by that of the microbes, and which have the power of destroying either the microbes against which immunity is possessed, or the products on which their pathogenic action depends.
Biochemistry
The Department of Biochemistry is internationally recognized for its research and education and offers a world-class interdisciplinary research environment in a beautiful mountain setting. As part of
SPECIAL SECTION: MEMBRANE PROTEINS CURRENT SCIENCE
  • SPECIAL SECTION: MEMBRANE PROTEINS CURRENT SCIENCE
  • 2004
J. Biol. Chem
  • J. Biol. Chem
  • 2003
J. Biol. Chem
  • J. Biol. Chem
  • 2003
J. Biol. Chem
  • J. Biol. Chem
  • 2003
J. Cell Sci
  • J. Cell Sci
  • 2003
Mol. Cell Biol
  • Mol. Cell Biol
  • 2003
Trends Cell Biol
  • Trends Cell Biol
  • 2003
J. Biol. Chem
  • J. Biol. Chem
  • 2002
...
1
2
3
4
5
...