Protein oxidative modifications in the ageing brain: consequence for the onset of neurodegenerative disease.

@article{Grimm2011ProteinOM,
  title={Protein oxidative modifications in the ageing brain: consequence for the onset of neurodegenerative disease.},
  author={Stefanie rer. nat. Grimm and Annika Hoehn and Kelvin J A Davies and Tilman Grune},
  journal={Free radical research},
  year={2011},
  volume={45 1},
  pages={
          73-88
        }
}
The free radical theory of ageing proposes the accumulation of altered, less active and toxic molecules of DNA, RNA, proteins and lipids caused by reactive oxygen species and reactive nitrogen species. Neurodegenerative disorders are characterized by an abnormal accumulation of oxidatively damaged macromolecules inside cells and in the extracellular space. Proteins involved in the formation of aggregates are β-amyloid, tau, α-synuclein, parkin, prion proteins and proteins containing… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 181 REFERENCES

Parkinson’s disease: molecules implicated in the formation and degradation of alpha-synuclein aggregates

  • S Engelender, Z Kaminsky, X Guo, AH Sharp, RK Amaravi
  • Neuropathology
  • 2007
Highly Influential
6 Excerpts

A role for alpha-synuclein in the regulation of dopamine biosynthesis

  • SY Kao, FJ Lee, W Song, LW Jin, BA. Yankner
  • J Neurosci
  • 2002
Highly Influential
6 Excerpts

Alphasynuclein promotes mitochondrial defi cit and oxidative stress

  • J Wong, T Takenouchi, M Hashimoto, E. Masliah
  • Am J Pathol
  • 2000
Highly Influential
6 Excerpts

Apolipoprotein E iso

  • L Baum, L Chen, HK Ng, CP. Pang
  • 1999
Highly Influential
5 Excerpts

Lipofuscin-like fl uorophores

  • K. Uchida
  • matures. Physiol Rev ;78:547
  • 1998
Highly Influential
8 Excerpts

Alzheimer’s disease. CNS Neurol Disord Drug Targets

  • RA Cherny, CS Atwood, ME Xilinas, DN Gray, WD Jones
  • 2010
1 Excerpt

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