Protein oxidative damage in a transgenic mouse model of familial amyotrophic lateral sclerosis.

@article{Andrus1998ProteinOD,
  title={Protein oxidative damage in a transgenic mouse model of familial amyotrophic lateral sclerosis.},
  author={Paula K Andrus and Timothy J. Fleck and Mark E Gurney and Edward D. Hall},
  journal={Journal of neurochemistry},
  year={1998},
  volume={71 5},
  pages={2041-8}
}
The Gly93-->Ala mutation in the Cu,Zn superoxide dismutase (Cu,Zn-SOD) gene (SOD1) found in some familial amyotrophic lateral sclerosis (FALS) patients has been shown to result in an aberrant increase in hydroxyl radical production by the mutant enzyme that may cause oxidative injury to spinal motor neurons. In the present study, we analyzed the extent of oxidative injury to lumbar and cervical spinal cord proteins in transgenic FALS mice that overexpress the SOD1 mutation [TgN(SOD1-G93A)G1H… CONTINUE READING
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