Protein oxidation and proteolysis

  title={Protein oxidation and proteolysis},
  author={Nicolle Bader and Tilman Grune},
  booktitle={Biological chemistry},
Abstract One of the hallmarks of chronic or severe oxidative stress is the accumulation of oxidized proteins, which tend to form high-molecular-weight aggregates. The major proteolytic system responsible for the removal of oxidized cytosolic and nuclear proteins is the proteasome. This complicated proteolytic system contains a core proteasomal form (20S proteasome) and several regulators. All of these components are affected by oxidative stress to various degrees. The ATP-stimulated 26S… 

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