Protein oxidation: prime suspect found ‘not guilty’

  title={Protein oxidation: prime suspect found ‘not guilty’},
  author={Martin Bader and Jakob R Winther and James C. A. Bardwell},
  journal={Nature Cell Biology},
prime suspect in the oxidation of proteins has now been declared to be an innocent victim by Cuozzo and Kaiser on page 130 of this issue of Nature Cell Biology. Most proteins that are destined for secretion from the eukaryotic cell are tied by disulphide bonds while passing through the endoplasmic reticulum (ER), one of the organelles that secretory proteins must journey through on their way to the cell surface. Intramolecular disulphides, which act to crosslink cysteine residues, are important… CONTINUE READING