Protein overload stimulates RANTES production by proximal tubular cells depending on NF-kappa B activation.

@article{Zoja1998ProteinOS,
  title={Protein overload stimulates RANTES production by proximal tubular cells depending on NF-kappa B activation.},
  author={Carlamaria Zoja and Roberta Donadelli and Silvia Colleoni and Marina Figliuzzi and Samantha Bonazzola and Marina Morigi and Giuseppe Remuzzi},
  journal={Kidney international},
  year={1998},
  volume={53 6},
  pages={
          1608-15
        }
}
Abnormal traffic of proteins through the glomerular capillary has an intrinsic renal toxicity possibly linked to the subsequent process of proximal tubular reabsorption. Here we investigated in vitro the effect of protein overload on proximal tubular cell production of RANTES, a nuclear factor-kappa B (NF-kappa B)-dependent chemokine with potent chemotactic activity for monocytes/macrophages and T lymphocytes. Confluent pig LLC-PK1 cells were incubated for 24 and 48 hours with Eagle's MEM plus… CONTINUE READING
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