Protein-only transmission of three yeast prion strains

@article{King2004ProteinonlyTO,
  title={Protein-only transmission of three yeast prion strains},
  author={C King and Ruben Diaz-Avalos},
  journal={Nature},
  year={2004},
  volume={428},
  pages={319-323}
}
Key questions regarding the molecular nature of prions are how different prion strains can be propagated by the same protein and whether they are only protein. Here we demonstrate the protein-only nature of prion strains in a yeast model, the [PSI] genetic element that enhances the read-through of nonsense mutations in the yeast Saccharomyces cerevisiae. Infectious fibrous aggregates containing a Sup35 prion-determining amino-terminal fragment labelled with green fluorescent protein were… CONTINUE READING
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