Protein-nucleic acid interactions of LINE-1 ORF1p.

Abstract

Long interspersed nuclear element 1 (LINE-1 or L1) is the dominant retrotransposon in mammalian genomes. L1 encodes two proteins ORF1p and ORF2p that are required for retrotransposition. ORF2p functions as the replicase. ORF1p is a coiled coil-mediated trimeric, high affinity RNA binding protein that packages its full- length coding transcript into an ORF2p… (More)
DOI: 10.1016/j.semcdb.2018.03.019

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