Protein networks supporting AP-3 function in targeting lysosomal membrane proteins.

@article{Baust2008ProteinNS,
  title={Protein networks supporting AP-3 function in targeting lysosomal membrane proteins.},
  author={Thorsten Baust and Mihaela Anitei and Cornelia Czupalla and Iryna Parshyna and Line Bourel and Christoph Thiele and Eberhard Krause and Bernard Hoflack},
  journal={Molecular biology of the cell},
  year={2008},
  volume={19 5},
  pages={
          1942-51
        }
}
The AP-3 adaptor complex targets selected transmembrane proteins to lysosomes and lysosome-related organelles. We reconstituted its preferred interaction with liposomes containing the ADP ribosylation factor (ARF)-1 guanosine triphosphatase (GTPase), specific cargo tails, and phosphatidylinositol-3 phosphate, and then we performed a proteomic screen to identify new proteins supporting its sorting function. We identified approximately 30 proteins belonging to three networks regulating either AP… CONTINUE READING