Protein motion in the nucleus: from anomalous diffusion to weak interactions

  title={Protein motion in the nucleus: from anomalous diffusion to weak interactions},
  author={Maxime Woringer and Xavier Darzacq},
  journal={Biochemical Society Transactions},
  pages={945 - 956}
Understanding how transcription factors (TFs) regulate mammalian gene expression in space and time is a central topic in biology. To activate a gene, a TF has first to diffuse in the available space of the nucleus until it reaches a target DNA sequence or protein (target site). This eventually results in the recruitment of the whole transcriptional machinery. All these processes take place in the mammalian nucleoplasm, a highly organized and dynamic environment, in which some complexes… 

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