Protein modules and signalling networks

@article{Pawson1995ProteinMA,
  title={Protein modules and signalling networks},
  author={Tony Pawson},
  journal={Nature},
  year={1995},
  volume={373},
  pages={573-580}
}
  • T. Pawson
  • Published 16 February 1995
  • Biology
  • Nature
Communication between cells assumes particular importance in multicellular organisms. The growth, migration and differentiation of cells in the embryo, and their organization into specific tissues, depend on signals transmitted from one cell to another. In the adult, cell signalling orchestrates normal cellular behaviour and responses to wounding and infection. The consequences of breakdowns in this signalling underlie cancer, diabetes and disorders of the immune and cardiovascular systems… 
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References

SHOWING 1-10 OF 127 REFERENCES
Regulation and function of the Rho subfamily of small GTPases.
Proteins regulating Ras and its relatives
TLDR
Many of these proteins are much larger and more complex than their targets, containing multiple domains capable of interacting with an intricate network of cellular enzymes and structures.
C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains
TLDR
The results indicate that the sem-5 gene encodes a novel protein that functions in at least two distinct cell-signalling processes, both in vulval induction and in sex myoblast migration.
SH2 and SH3 domains
A mitotic function for Src?
A yeast gene (BEM1) necessary for cell polarization whose product contains two SH3 domains
TLDR
The isolation of two mutants defective specifically in cell polarization in response to peptide mating pheromones is described, which indicates that it may link the cytoskeleton to morphogenetic determinants on the cell surface.
Association between GTPase activators for Rho and Ras families
TLDR
It is shown here that p190 can function as a GAP specifically for members of the rho family, and the formation of a complex between Ras-GAP and p190 in growth-factor stimulated cells may allow the coupling of signalling pathways that involve ras and rho GTPases.
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.
TLDR
A previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that phosphorylate substrate proteins called STATs (signal transducers and activators of transcription).
A target for Src in mitosis
TLDR
It is reported here that although phosphorylation of most proteins was unchanged during mitosis, phosphorylated of one of about 68K was greatly enhanced, and it was related to the previously described GAP-associated protein p62 (ref. 6).
...
1
2
3
4
5
...