Protein modifications during antiviral heat bioprocessing and subsequent storage.

@article{Smales2001ProteinMD,
  title={Protein modifications during antiviral heat bioprocessing and subsequent storage.},
  author={Christopher Mark Smales and Duncan S Pepper and David R. C. James},
  journal={Biotechnology progress},
  year={2001},
  volume={17 5},
  pages={974-8}
}
Antiviral heat treatment is routinely used in the bioprocessing of therapeutic proteins as a means of reducing viral load. However, in protein formulations containing sucrose this form of bioprocessing can lead to protein modifications. Using a model protein, hen egg white lysozyme, we investigated the effects of antiviral heat treatments in the presence of… CONTINUE READING