Protein misfolding, aggregation, and degradation in disease

@article{Gregersen2005ProteinMA,
  title={Protein misfolding, aggregation, and degradation in disease},
  author={N. Gregersen and L. Bolund and P. Bross},
  journal={Molecular Biotechnology},
  year={2005},
  volume={31},
  pages={141-150}
}
Pathologies associated with protein misfolding have been observed in neurodegenerative diseases such as Alzheimer’s disease, metabolic diseases like phenylketonuria, and diseases affecting structural proteins like collagen or keratin. Misfolding of mutant proteins in these and many other diseases may result in premature degradation, formation of toxic aggregates, or incorporation of toxic conformations into structures. We review common traits of these diverse diseases under the unifying view of… Expand
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References

SHOWING 1-10 OF 65 REFERENCES
Roles of molecular chaperones in protein misfolding diseases.
  • 295
Protein misfolding and disease; protein refolding and therapy
  • C. Soto
  • Biology, Medicine
  • FEBS letters
  • 2001
  • 317
Degradation of mutant proteins, underlying "loss of function" phenotypes, plays a major role in genetic disease.
  • P. Waters
  • Biology, Medicine
  • Current issues in molecular biology
  • 2001
  • 33
  • PDF
Misfolding, Degradation, and Aggregation of Variant Proteins
  • 68
  • PDF
...
1
2
3
4
5
...