Protein microarray analysis as a tool for monitoring cellular autoreactivity in type 1 diabetes patients and their relatives.

Abstract

BACKGROUND Autoreactive T cells have a crucial role in type 1 diabetes (T1D) pathogenesis. OBJECTIVES The aim of our study was to monitor the in vitro production of cytokines by peripheral blood mononuclear cells (PBMCs) after stimulation with diabetogenic autoantigens. SUBJECTS Ten T1D patients (tested at the time of diagnosis and 6 and 12 months later… (More)

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