Protein-mediated molecular bridging: a key mechanism in biopolymer organization.


Protein-mediated bridging is ubiquitous and essential for shaping cellular structures in all organisms. Here we dissect this mechanism for a model system: the Histone-like Nucleoid-Structuring protein (H-NS). We present data from two complementary single-molecule assays that probe the H-NS-DNA interaction: a dynamic optical-trap-driven unzipping assay and… (More)
DOI: 10.1016/j.bpj.2009.06.051


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