Protein-mediated dethreading of a biotin-functionalised pseudorotaxane.

@article{Caldwell2014ProteinmediatedDO,
  title={Protein-mediated dethreading of a biotin-functionalised pseudorotaxane.},
  author={S. Caldwell and C. Maclean and M. Riehle and A. Cooper and M. Nutley and G. Rabani and B. Fitzpatrick and V. Rotello and Brian O. Smith and Belal Khaled and P. Woisel and G. Cooke},
  journal={Organic & biomolecular chemistry},
  year={2014},
  volume={12 3},
  pages={
          511-6
        }
}
In this article, we describe the synthesis of new biotin-functionalised naphthalene derivatives 3 and 4 and their complexation behaviour with avidin and neutravidin using a range of analytical techniques. We have shown using 2-(4'-hydroxyazobenzene)benzoic acid displacement and ITC experiments, that compounds 3 and 4 have the propensity to form reasonably high-affinity bioconjugates with avidin and neutravidin. We have also demonstrated using (1)H NMR, UV-vis and fluorescence spectroscopy that… Expand
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References

SHOWING 1-10 OF 79 REFERENCES
Three-dimensional structures of avidin and the avidin-biotin complex.
Chicken Avidin Exhibits Pseudo-catalytic Properties
Host-[2]rotaxanes as cellular transport agents.
A self-assembled multivalent pseudopolyrotaxane for binding galectin-1.
Tuneable pseudorotaxane formation between a biotin-avidin bioconjugate and CBPQT4+.
...
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3
4
5
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