Protein maintenance in aging and replicative senescence: a role for the peptide methionine sulfoxide reductases.

Abstract

Cellular aging is characterized by the build-up of oxidatively modified protein that results, at least in part, from impaired redox homeostasis associated with the aging process. Protein degradation and repair are critical for eliminating oxidized proteins from the cell. Oxidized protein degradation is mainly achieved by the proteasomal system and it is now… (More)

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@article{Petropoulos2005ProteinMI, title={Protein maintenance in aging and replicative senescence: a role for the peptide methionine sulfoxide reductases.}, author={Isabelle Petropoulos and Bertrand Friguet}, journal={Biochimica et biophysica acta}, year={2005}, volume={1703 2}, pages={261-6} }