Protein machines and lipid assemblies: current views of cell membrane fusion.

@article{Lentz2000ProteinMA,
  title={Protein machines and lipid assemblies: current views of cell membrane fusion.},
  author={Barry R. Lentz and Vladimir S Malinin and Md Emdadul Haque and Kate Evans},
  journal={Current opinion in structural biology},
  year={2000},
  volume={10 5},
  pages={607-15}
}
Protein machines and lipid bilayers both play central roles in cell membrane fusion, a process crucial to life. Recent results provide clues to how both components function in fusion. Recent observations suggest a common mechanism by which very different fusion machines (from lipid-enveloped viruses and synaptic vesicles) may function to produce compartment-joining pores. This mechanism presumes that fusion proteins act as machines that use stored conformational energy to assemble closely… CONTINUE READING

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