Protein localization to the nucleolus: a search for targeting domains in nucleolin.

@article{SchmidtZachmann1993ProteinLT,
  title={Protein localization to the nucleolus: a search for targeting domains in nucleolin.},
  author={Marion S. Schmidt-Zachmann and Erich A. Nigg},
  journal={Journal of cell science},
  year={1993},
  volume={105 ( Pt 3)},
  pages={799-806}
}
Nucleolin, a major nucleolar phosphoprotein, is presumed to function in rDNA transcription, rRNA packaging and ribosome assembly. Its primary sequence was highly conserved during evolution and suggests a multi-domain structure. To identify structural elements required for nuclear uptake and nucleolar accumulation of nucleolin, we used site-directed mutagenesis to introduce point- and deletion-mutations into a chicken nucleolin cDNA. Following transient expression in mammalian cells, the… CONTINUE READING
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Structure and function of the nuclear pore complex

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