Protein-linked RNA of poliovirus is competent to form an initiation complex of translation in vitro

@article{Golini1980ProteinlinkedRO,
  title={Protein-linked RNA of poliovirus is competent to form an initiation complex of translation in vitro},
  author={Fred Golini and Bert L Semler and Andrew J. Dorner and Eckard J Wimmer},
  journal={Nature},
  year={1980},
  volume={287},
  pages={600-603}
}
Poliovirus RNA that had been labelled with 125I in the 5′-terminal protein (VPg) was found competent to form an initiation complex of translation in a cell-free reticulocyte lysate. In conditions of ribosome binding, no cleavage occurred between VPg and RNA. We conclude that removal of VPg from poliovirus RNA is not a prerequisite for this RNA to initiate translation in vitro.