Protein-like tertiary folding behavior from heterogeneous backbones.

  title={Protein-like tertiary folding behavior from heterogeneous backbones.},
  author={Zachary E Reinert and George A Lengyel and W Seth Horne},
  journal={Journal of the American Chemical Society},
  volume={135 34},
Because proteins play vital roles in life, much effort has been invested in their mimicry by synthetic agents. One approach is to design unnatural backbone oligomers ("foldamers") that fold like natural peptides. Despite success in secondary structure mimicry by such species, protein-like tertiary folds remain elusive. A fundamental challenge underlying… CONTINUE READING