Protein levels of β-catenin and activation state of glycogen synthase kinase-3β in major depression. A study with postmortem prefrontal cortex.

@article{Karege2012ProteinLO,
  title={Protein levels of β-catenin and activation state of glycogen synthase kinase-3β in major depression. A study with postmortem prefrontal cortex.},
  author={F{\'e}licien Karege and Nader Ali Perroud and Sandra Burkhardt and Rafael Fernandez and Eladia Ballmann and Romano La Harpe and Alain Malafosse},
  journal={Journal of affective disorders},
  year={2012},
  volume={136 1-2},
  pages={185-188}
}
BACKGROUND The Wnt/GSK3β signaling pathway was implicated in mood disorders. Beta-catenin is a protein targeted by this signaling axis. We aimed to examine whether there is an abnormality in this signaling axis in major depression. METHODS Postmortem brains from 20 depressed and 20 non-depressed subjects were used. In both groups, suicide and non-suicide were included in equal number. Protein levels of β-catenin, tGSK3β and ser(9)-pGSK3β were determined in prefrontal cortex. RESULTS ANOVA… CONTINUE READING
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