Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling

  title={Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling},
  author={T. Hunter},
  • T. Hunter
  • Published 1995
  • Biology, Medicine
  • Cell
  • Protein phosphorylation plays a cardinal role in regulating many cellular processes in eukaryotes. In particular, protein phosphorylation is a major currency of signal transduction pathways. Processes that are reversibly controlled by protein phosphorylation require not only a protein kinase (PK) but also a protein phosphatase (PP). Target proteins are phosphorylated at specific sites by one or more PKs, and these phosphates are removed by specific PPs. In principle, the extent of… CONTINUE READING
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