Protein kinases G are essential downstream mediators of the antifibrotic effects of sGC stimulators.

Abstract

OBJECTIVES Stimulators of soluble guanylate cyclase (sGC) are currently investigated in clinical trials for the treatment of fibrosis in systemic sclerosis (SSc). In this study, we aim to investigate the role of protein kinases G (PKG) as downstream mediators of sGC-cyclic guanosine monophosphate (cGMP) in SSc. METHODS Mice with combined knockout of PKG1… (More)
DOI: 10.1136/annrheumdis-2017-212489

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