Protein kinases C-gamma and -delta are involved in insulin-like growth factor I-induced migration of colonic epithelial cells.

@article{Andr1999ProteinKC,
  title={Protein kinases C-gamma and -delta are involved in insulin-like growth factor I-induced migration of colonic epithelial cells.},
  author={Fr{\'e}d{\'e}ric Andr{\'e} and V{\'e}ronique Rigot and Maryse M. Remacle-Bonnet and Jose Luis and Gilbert J. Pommier and Jacques Marvaldi},
  journal={Gastroenterology},
  year={1999},
  volume={116 1},
  pages={
          64-77
        }
}
BACKGROUND & AIMS The mechanisms by which epithelial cells migrate during the repair of damaged colonic mucosa are poorly understood. This study investigated the insulin-like growth factor I (IGF-I) signaling pathway leading to HT29-D4 human colonic epithelial cell line migration. METHODS IGF-stimulated cell migration was determined using a wound model in the presence or absence of kinase inhibitors. Activation of protein kinase C (PKC) was determined by immunodetection. RESULTS IGF-I and… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 18 CITATIONS

Similar Papers

Loading similar papers…