Protein kinases A and C phosphorylate purified Ca2+-ATPase from rat cortex, cerebellum and hippocampus.

@article{Zylinska1998ProteinKA,
  title={Protein kinases A and C phosphorylate purified Ca2+-ATPase from rat cortex, cerebellum and hippocampus.},
  author={Ludmila Zylinska and Danilo Guerini and E Gromadzińska and Lilla Lachowicz},
  journal={Biochimica et biophysica acta},
  year={1998},
  volume={1448 1},
  pages={99-108}
}
The plasma membrane Ca2+-ATPase (PMCA), the enzyme responsible for the maintenance of intracellular calcium homeostasis, is regulated by several independent mechanisms. In this paper we report that the protein kinases A and C differentially activate the Ca2+-ATPase purified from synaptosomal membranes of rat cortex, cerebellum and hippocampus. The effect of protein kinases was more pronounced for the cortical enzyme, whereas cerebellar and hippocampal Ca2+-ATPases were activated to a lesser… CONTINUE READING