Protein kinases: evolution of dynamic regulatory proteins.

  title={Protein kinases: evolution of dynamic regulatory proteins.},
  author={Susan S. Taylor and Alexandr P. Kornev},
  journal={Trends in biochemical sciences},
  volume={36 2},
Eukayotic protein kinases evolved as a family of highly dynamic molecules with strictly organized internal architecture. A single hydrophobic F-helix serves as a central scaffold for assembly of the entire molecule. Two non-consecutive hydrophobic structures termed "spines" anchor all the elements important for catalysis to the F-helix. They make firm, but flexible, connections within the molecule, providing a high level of internal dynamics of the protein kinase. During the course of evolution… CONTINUE READING
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