Protein kinase inhibitors in renal cell carcinoma.

@article{Daste2014ProteinKI,
  title={Protein kinase inhibitors in renal cell carcinoma.},
  author={Amaury Daste and Thomas Grellety and Marine Gross-Goupil and Alain Mure Ravaud},
  journal={Expert opinion on pharmacotherapy},
  year={2014},
  volume={15 3},
  pages={337-51}
}
INTRODUCTION Metastatic Renal Cell Carcinoma (mRCC) was historically treated with cytokine therapy with a poor outcome. In the last decade, new therapies targeting vascular endothelial growth factor (VEGF) or the mammalian target of rapamycin (m-TOR) pathways demonstrated efficacy in mRCC. Protein kinase inhibitors as well as monoclonal antibodies targeting these pathways have become the standard treatment of renal cell carcinoma (RCC) in the first-line setting and beyond. AREAS COVERED This… CONTINUE READING

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