Protein kinase inhibition: different approaches to selective inhibitor design.

@article{Scapin2006ProteinKI,
  title={Protein kinase inhibition: different approaches to selective inhibitor design.},
  author={Giovanna Scapin},
  journal={Current drug targets},
  year={2006},
  volume={7 11},
  pages={
          1443-54
        }
}
Protein kinases represent a large family of enzymes involved in regulating complex molecular machineries that control many cellular functions, from survival and proliferation to apoptosis. Abnormal protein kinase activity has been involved in a variety of pathophysiologic states, including cancer, inflammatory and autoimmune disorders, and cardiac diseases, and protein kinases have become one of the major therapeutical targets of the past 10 years. The major problem associated with ATP… CONTINUE READING

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