Protein kinase-dependent overexpression of the nuclear protein pirin in c-JUN and RAS transformed fibroblasts

Abstract

Signalling via the protein kinase Raf-MEK-ERK pathway is of major importance for transformation by oncogenes. To identify genes affected by inhibition of this pathway, c-JUN transformed rat fibroblasts were treated with a MEK1 inhibitor (PD98059) and subjected to two-dimensional gel electrophoresis after cell lysis. Gene products with expression influenced… (More)
DOI: 10.1007/s000180050303

Topics

3 Figures and Tables

Cite this paper

@article{Bergman1999ProteinKO, title={Protein kinase-dependent overexpression of the nuclear protein pirin in c-JUN and RAS transformed fibroblasts}, author={A S Bergman and Ayodele A. Alaiya and Waltraut Wendler and Bernard Bin{\'e}truy and Michal S Shoshan and Kohsaku Sakaguchi and Tomas Bergman and Ulrike Kronenwett and Gerald Auer and Ettore Appella and Henrik J{\"o}rnvall and Susan M Linder}, journal={Cellular and Molecular Life Sciences CMLS}, year={1999}, volume={55}, pages={467-471} }