Protein kinase R regulates double-stranded RNA induction of TNF-alpha but not IL-1 beta mRNA in human epithelial cells.

@article{Meusel2002ProteinKR,
  title={Protein kinase R regulates double-stranded RNA induction of TNF-alpha but not IL-1 beta mRNA in human epithelial cells.},
  author={Tiffany R. Meusel and Kelly E. Kehoe and Farhad Imani},
  journal={Journal of immunology},
  year={2002},
  volume={168 12},
  pages={6429-35}
}
Epithelial cells represent the initial site of respiratory viral entry and the first line of defense against such infections. This early antiviral response is characterized by an increase in the production of proinflammatory cytokines such as TNF-alpha and IL-1 beta. dsRNA, which is a common factor present during the life cycle of both DNA and RNA viruses, is known to induce TNF-alpha and IL-1 beta in a variety of cells. In this work we provide data showing that dsRNA treatment induces TNF… CONTINUE READING
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